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Image Search Results
Journal: Frontiers in Molecular Biosciences
Article Title: Global and Comparative Proteome Signatures in the Lens Capsule, Trabecular Meshwork, and Iris of Patients With Pseudoexfoliation Glaucoma
doi: 10.3389/fmolb.2022.877250
Figure Lengend Snippet: Protein profiles in LC with PXG compared to PXF. (A) Box plot of the protein expressions in each sample of PXF and PXG ( n = 3), showing very little variability among the triplicate samples. (B) Abundance ratios (log2) of proteins in PXF vs. PXG with overexpressed or underexpressed proteins indicated in the graph. (C) Venn list was derived of all 1,433 proteins in PXF vs. control, PXG vs. control, and PXF vs. PXG for the identification of common and unique proteins in PXF and PXG. (D) Network generated of protein–protein interactomes with the top 27 proteins identified in PXG (> 2.5 folds) involved in extracellular homeostasis and protein binding using STRING analysis. (E) Fold change of cytokines/chemokines using a bioplex kit assay with PXG compared to PXF. Means ± SEM shown, * p < 0.05, ** p < 0.01, one-way ANOVA post hoc t -test with Tukey correction, PXF-pseudoexfoliation, and PXG-pseudoexfoliation glaucoma.
Article Snippet: The concentration of cytokines in the extracted protein samples from tissues was evaluated using a
Techniques: Derivative Assay, Control, Generated, Protein Binding
Journal: Frontiers in Molecular Biosciences
Article Title: Global and Comparative Proteome Signatures in the Lens Capsule, Trabecular Meshwork, and Iris of Patients With Pseudoexfoliation Glaucoma
doi: 10.3389/fmolb.2022.877250
Figure Lengend Snippet: Protein profile in LC with PXG compared to the control. (A) Abundance ratios (log2) of proteins overexpressed or underexpressed are indicated in the graph. (B) Fold change of cytokines/chemokines using a bioplex kit assay with PXG compared to the control. (C) Functional enrichment protein analysis by the FunRich database tool using 43 proteins subjected to this analysis. The percentage of the cellular component highlights chylomicron more enriched in PXG. (D) Molecular functions such as heparan sulfate proteoglycan binding and protein-membrane adaptor activity are more enriched in PXG. (E) Biological process classifications such as peptide cross-linking are more enriched in PXG. Means ± SEM shown, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, one-way ANOVA post hoc t -test with Tukey correction, PXG-pseudoexfoliation glaucoma.
Article Snippet: The concentration of cytokines in the extracted protein samples from tissues was evaluated using a
Techniques: Control, Functional Assay, Binding Assay, Membrane, Activity Assay